MARSEIL (Multi Approaches for the Research of Synthesis by Efficient and Interactive Logic) was the name of a system which will offer several programs to the chemist to solve a synthesis problem.
The first program developed was a new version of SOS for Macintosh which was inoventive on several points. This version was friendly user thanks to the Macintosh interface. The main new characteristics were : (i) the program was open to the user who may add his own perception of the target during the analysis part ; (ii) the input of reactions, i.e. the knowledge base of the system, was mainly graphic ; (iii) a graphical description of the bibliography was associated with each reaction ; (iv) graphical tests were developed ; (v) possibility to modify the evaluation tests during the retrosynthesis, which gave a property of self-learning to the program.

Some views of the program :

New synthesis of yohimbine found by the program :

New synthesis of bulnesol found by the program :

Papers about MARSEIL :

29 - Microcomputer and organic synthesis. The Marsel/SOS expert system. A new graphic approach. An electronic lab note for organic synthesis.
P. Azario, R. Barone and M. Chanon.
J. Org. Chem., 1988, 53, 720-724.
34 - Aide de l' Ordinateur en Synthèse Organique.
P. Azario, M. Arbelot, A. Baldy, R. Barone and M. Chanon.
Science Technique Technologie. 1990, 13, 28-33.
35 - Microcomputer Assisted RetroSynthesis.
P. Azario, M. Arbelot, A. Baldy, R. Meyer, R. Barone and M. Chanon
New J. Chem., 1990, 14, 951-956.

MARSEIL/SOS has been also used to search for the key step of a synthesis (see ref. 31 and 38) and to study the formation of aroma compounds (see ref. 37). It is discussed in HOLOWin and GRAAL sections.

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