1973 : First version of SOS (Simulated Organic Synthesis). It was running on an IBM 1130 with a memory of 32 Ko. The program was typed on punched cards !

1974 : Use of mechanisms to code reactions in SOS

1979 : SOS was adapted to organometallic chemistry in M.L.H. Green laboratory (Oxford)

1980 : Use of SOS as a combinatorial chemistry program for the Maillard reaction

1982 : SOS was adapted on an Apple II microcomputer (48 Ko memory, 1 MHz).

1985 : TAMREAC : a specific program devoted to organometallic chemistry in homogeneous catalysis (Jason Theodosiou PHD)

1986 : REKEST : a simple program to search for the key step of a synthesis.

1988 : SOS was improved and adapted for Macintosh : MARSEIL program (Patrick Azario PHD).

1989 : Use of MARSEIL to search for the key step of a synthesis.

1994 : A version of SOS with stereochemistry for IBM/PC was developed (André Bertrand PHD)

1995 : CONAN : a new approach to search for the key steps of a synthesis.

1996 : HOLOWin : a program to search for the key step of a synthesis (Frederic Barberis PHD)

1998 : SESAM : a simple approach to search for the starting materials of a synthesis

2000 : CHIC : a new program in the field of Combinatorial Chemistry (developed for Sanofi).

2001 : GASP : a program to generate automatically polycyclic structures.

2001 : GRAAL : another program in the field of Combinatorial Chemistry.

2005 : CONAN : a new approach for Windows

2006 : WTDWTR : What To Do With This Reaction ? A New Approach in the Field of Computer-Aided Organic Synthesis.

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